This series, constituting the largest in the collection, aptly demonstrates the effort expended by Miriam Young Holden in her work of researching the history of women as well as her active involvement in contemporary women's rights movements. The vast array of detailed subjects illustrates Holden's passion for discovering the role women have played in not only modern American history, but also in ancient and global history. The large amounts of materials related to contemporary women's issues also point to her work in groups such as the National Woman's Party and the World Center for Women's Archives.

Many files include newspaper clippings, book reviews, notes written by Holden, or original materials. There is also an extensive amount of materials related to the Equal Rights Amendment (mostly during the 1960s), libraries, education, and specific women in history. One of the larger sections of this series consists of materials on women in specific occupations, roles, time periods, etc. (see files beginning with Woman, Women, or Women's).

Historical materials of note include original correspondence or materials of Belva Lockwood, Susan B. Anthony, Lydia Maria Child, Dorothea Dix, Caroline Norton, Alice Paul, and Victoria Woodhull. There are also several original sermons (mid-19th-century) and an autograph song by Victoria Woodhull on the Beecher & Tilton Scandal.

This series, however, also demonstrates that it was not just women's history that Miriam Young Holden was interested, but that she had a much broader curiosity, with subjects ranging from alcoholism, to art, to literature. Also included are files on religion, race, social theories, animals, hurricanes, and Long Island, among others.