Consists of manuscripts related to four generations of the Blanco White family, spanning two centuries: works, diaries, correspondence, documents, accounts and expense records, and printed material. Joseph Blanco White, the Spanish-English writer and religious figure, remains the focus of the collection; however, his brother Fernando, a politician and intellectual of 19th-century Seville, also accounts for a substantial part of the material.

Included are autograph manuscripts of several of Joseph's literary efforts-- Cartas Sobre España (novel first published in English in 1822), Luisa De Bustamante (unfinised novel, 1839-1840), "Reader, thou look'st upon a barren page..." (poem, 1837); Fernando's diaries (1808-1814, 1817, 1820-1829, 1834-1848), which document daily activities in 19th-century Spain; correspondence, particularly by and to Joseph, Fernando, and their father, Guillermo, showing the development of Joseph's political and religious ideas, Fernando's ambitions, and family affairs; and academic, ecclesiastical, municipal, and legal documents that support Joseph and Fernando's various careers.

Also included are 19th-century Spanish school exercises, sermons, and prayers, and family birth, wedding, and death certificates, as well as other genealogical material relating to the Blanco White family.