The collection comprises 17 archival boxes of manuscripts of some of Tsitselē's novels, short stories, radio scripts, translations of Greek works into English, and correspondence with friends and associates. Included in these papers are autograph manuscript and typescript drafts, as well as notebooks of No Name in the Street (1953), her first novel, Ten Seconds from Now (1957), a novel, The Way to Colonos (1960), and many drafts of stories to be included in an unpublished work, The Painter and His Model (ca. 1978). In addition, there are translations from Greek into English by Tsitselē of Koula (1991) by Menēs Koumantareas and The Wife of Candaulus (1954) by Margarita Lymperakē, as well as a libretto for an opera composed by Arghyris Kounadis called The Return (1962), based on The Way to Colonos.

There are letters to Tsitselē, in English and in Greek, by Michael Cacoyannis, Kimon Friar, E. M. Forster, W. Hollerer, Margarita Lymperakē, Iris Murdoch, Peter Mackridge, Arghyris Kounadis, Angelos Staurou Vlachos, and others; literary and other magazines; and Greek newspapers containing articles, book reviews or short stories by Tsitselē. Also included are postcard photographs by Sougioutzoglou-Seraidarē, Nelly's of the Delphic Festival of 1930 in Delphi, Greece, and a few others.